Norovirus Replication and Immune Evasion

Grant number: 1083139 | Funding period: 2015 - 2017

Completed

Abstract

Viral gastroenteritis poses an enormous burden in public health and is an emerging problem due to the acute nature of the infection process. We aim to understand how our bodies react to infection with Noroviruses, in particular how our immune system is triggered and unfortunately avoided during an infectious episode. We also aim to determine how Noroviruses utilized host components and pathways to facilitate infection in the body.

Related publications (14)

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Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death

JM Deerain, TE Aktepe, AM Trenerry, G Ebert, JL Hyde, K Charry, L Edgington-Mitchell, B Xu, RL Ambrose, ST Sarvestani, KE Lawlor, JS Pearson, PA White, JM Mackenzie

2024-01-01

Human norovirus is the leading cause of acute gastroenteritis worldwide, however despite the significance of this pathogen, we hav..

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Antiviral candidates for treating hepatitis E virus infection

NE Netzler, DE Tuipulotu, SG Vasudevan, JM Mackenzie, PA White

2019-06-01

Globally, hepatitis E virus (HEV) causes significant morbidity and mortality each year. Despite this burden, there are no specific..

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The adenosine analogue NITD008 has potent antiviral activity against human and animal caliciviruses

DE Tuipulotu, TM Fumian, NE Netzler, JM Mackenzie, PA White

2019-06-01

The widespread nature of calicivirus infections globally has a substantial impact on the health and well-being of humans and anima..

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Mouse norovirus infection arrests host cell translation uncoupled from the stress granule-PKR-eIF2α Axis

S Fritzlar, TE Aktepe, YW Chao, ND Kenney, MR McAllaster, CB Wilen, PA White, JM Mackenzie

2019-05-01

The integrated stress response (ISR) is a cellular response system activated upon different types of stresses, including viral inf..

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Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

H Dubois, F Sorgeloos, ST Sarvestani, L Martens, Y Saeys, JM MacKenzie, M Lamkanfi, G Van Loo, I Goodfellow, A Wullaert

2019-01-01

Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annual..

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The microtubule-associated innate immune sensor gef-h1 does not influence mouse norovirus replication in murine macrophages

S Fritzlar, PA White, JM Mackenzie

2019-01-01

Norovirus is an acute infection of the gastrointestinal tract causing rapid induction of vomiting and diarrhoea. The infection is ..

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Mouse norovirus infection reduces the surface expression of major histocompatibility complex class i proteins and inhibits CD8 T cell recognition and activation

S Fritzlar, S Jegaskanda, TE Aktepe, JE Prier, LE Holz, PA White, JM Mackenzie

2018-09-01

Human noroviruses are highly infectious single-stranded RNA (ssRNA) viruses and the major cause of nonbacterial gastroenteritis wo..

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TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation

DE Tuipulotu, NE Netzler, JH Lun, JM Mackenzie, PA White

2018-05-01

Norovirus infections are a significant health and economic burden globally, accounting for hundreds of millions of cases of acute ..

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The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection

ST Sarvestani, JL McAuley

2017-12-01

The innate immune system provides the host with both a dynamic barrier to prevent infection and a means to which rapid anti-microb..

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Broad-spectrum non-nucleoside inhibitors for caliciviruses

NE Netzler, D Enosi Tuipulotu, AA Eltahla, JH Lun, S Ferla, A Brancale, N Urakova, M Frese, T Strive, JM Mackenzie, PA White

2017-10-01

Viruses of the Caliciviridae cause significant and sometimes lethal diseases, however despite substantial research efforts, specif..

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RNA sequencing of Murine norovirus-infected cells reveals Transcriptional alteration of genes important to Viral recognition and antigen Presentation

DE Tuipulotu, NE Netzler, JH Lun, JM Mackenzie, PA White

2017-08-11

Viruses inherently exploit normal cellular functions to promote replication and survival. One mechanism involves transcriptional c..

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The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication

BT Cotton, JL Hyde, ST Sarvestani, SV Sosnovtsev, KY Green, PA White, JM Mackenzie

2017-01-01

Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampere..

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Mouse Norovirus infection promotes autophagy induction to facilitate replication but prevents final autophagosome maturation

TB O'Donnell, JL Hyde, JD Mintern, JM Mackenzie

2016-05-01

Autophagy is a cellular process used to eliminate intracellular pathogens. Many viruses however are able to manipulate this cellul..

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Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response

ST Sarvestani, B Cotton, S Fritzlar, TB O'Donnell, JM MacKenzie

2016-04-01

Noroviruses (NoVs) belong to the Caliciviridae family of viruses and are responsible for causing the majority of gastroenteritis o..

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